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Acid reflux might cause asthma symptoms through aspiration of fluid into the airways, or acid might irritate the esophagus and upper airway,

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according to the study. Corbie Hains, a spokesman for AstraZeneca, which makes Nexium, said that the drug is not indicated for use in asthma and asymptomatic GERD. In most people, he said, a 40-mg dose would suppress nearly all acid production in the stomach. "People need to follow their doctor's advice and take their asthma medications on a regular basis," he said. And asthma might trigger GERD when it causes difficulty breathing. Parental Stress Boosts Kids' Asthma Risk
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Printer-Friendly
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Format Email to a Friend. National Institutes of Health, included 412 people whose asthma was badly controlled even though they were being treated with inhaled corticosteroids. Although
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the two conditions may seem quite different, doctors have long suspected that they're linked, with each disorder possibly triggering the other.

"If you have questions or concerns because you're taking Nexium or another proton

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pump inhibitor, talk to your doctor." 2009. The rate of asthma events was 2.3 per person-year for the placebo group and 2.5 events per person-year
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the treatment group. "Our study sho this is not an effective practice," Wise said. "The vast use is around treatment of GERD and heartburn," he said.

News Articles

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Next Article. Doctors have suspected that if people with asthma breathe in during reflux, they might breathe irritating stomach fluids into the lungs. But a study in the issue of the New England Journal of Medicine repots that a PPI probably isn't going to help lessen wheezing in people with silent
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GERD. But some people have what's known as silent GERD, meaning they have no symptoms. Proton pump inhibitors work by suppressing acid production. There was no statistically significant difference between those who took Nexium and the placebo group with respect to asthma control, lung function, GERD symptoms,
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night awakenings and quality of life, the study found. All had either no
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symptoms or just minimal symptoms of GERD.

They took 40 milligrams of Nexium or a placebo twice a day. To reduce that possibility, doctors have been prescribing acid-suppressing medications known as proton pump inhibitors (PPI).

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The diaphragm may overinflate,
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and the extra pressure may cause the esophageal sphincter to herniate, allowing fluids to dane out of the stomach. According to Wise, people given the drug took a larger-than-standard dose. The study, which was funded by the American Lung
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Association and the U.S. "Patients with asthma that is not adequately controlled with the usual asthma medications, and who have no symptoms of heartburn, but who may or may not have silent GERD,
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don't seem to have any improvement of asthma when treated with esomeprazole
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(Nexium)," said one of the study's Harold Wise, a professor of medicine in the division of pulmonary and critical care medicine at Johns Hopkins University School of Medicine in Baltimore. "For those who have asthma and have GERD, we want to make sure they continue to take their
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medications as directed," Hains said.

Many people with asthma also have gastroesophageal reflux disease, or GERD. "These drugs are effective for treating heartburn, and if you have asthma and heartburn, then these drugs may well be used for those symptoms." Wise said the researchers were not advocating that anyone stop taking their medications, but that they should talk with their physicians.